Appropriate drug use in sheep and goats (Proceedings)


Appropriate drug use in sheep and goats (Proceedings)

Aug 01, 2011

Extralabel use of drugs in small ruminants can be a confusing issue, highlighted by complicated regulations, an openness for interpretation, and in individual animal's intended use. In this session, I will attempt to give an overview of the regulations regarding extralabel drug use in small ruminants, some guidance in decision-making, and resources I have found useful. This will only focus on sheep and goats. It is very important to note that the information provided is time-sensitive, subject to change at any time, and is based on my own interpretation of the regulations and should not be used as the final word in extralabel drug use decision-making.

There are a variety of agencies, acts, and research groups involved in the guidance of extralabel drug use in food animals, including FDA, USDA (biologics), EPA (pesticides), National Research Support Project #7 (NSRP-7), Animal Medicinal Drug Use Clarification Act (AMDUCA) of 1994, Minor Use and Minor Species (MUMS) Animal Health Act of 2004.

Some definitions per the FDA:
     • Extralabel : use of any approved drug (prescription or over the counter) in a manner that is not in accordance with the approved label or the package insert. [This may include use in a different species, route of administration, dosage or dosing frequency.]
     • Minor species: species other than cattle, horses, swine, chickens, turkeys, dogs and cats (sheep were a major species until 2000)
     • Drug: any compound for which the diagnosis, cure, treatment, mitigation, or prevention of a disease is claimed
     • Withdrawal time: the time at which 99% of animals would be expected to reach the tolerance level for drug residue

The FDA maintains a list of prohibited drugs for use in food animals. For these drugs, extralabel use in food animals is not allowed under any circumstances. The list currently includes: chloramphenicol, nitroimidazoles (including dimetridazole, metronidazole and ipronidazole), sulfonamides in adult dairy cattle (>20 months of age, except for on-label use of sulfadimethoxine), clenbuterol, dipyrone, fluoroquinolones, glycopeptides (vancomycin), nitrofurans (topical included in prohibition), phenylbutazone in adult dairy cattle, genetian violet.

Hot topics on dvm360

Can you save this client? (Yes.)

VETTED - Sep 19, 2016