Renal insufficiency/failure is the most common cause of morbidity and mortality in older cats. There are some specific degenerative
renal diseases (e.g. polycystic kidney disease of Persians and Persian-crossbreds, amyloidosis of Abyssinians), infectious
causes (e.g. FIP, chronic pyelonephritis), and neoplastic renal disease (most commonly LSA) that may lead to renal failure
in cats. However the most common cause of eventual renal failure is referred to as Chronic Progressive Renal Disease (CPRD).
By the time this condition is recognized, renal histopathology usually reflects end-stage renal disease and any initiating
insult usually cannot be identified. The most common histologic findings are those of chronic interstitial nephritis and lymphoplasmacytic
The first step in managing feline patients with CPRD is identification of affected individuals. All middle-aged to older cats
should receive at least once yearly historical assessment, thorough physical examination, and appropriate laboratory screening
for patient age. Lethargy and decreased appetite may be important owner observations. Owners should be asked about changes
in water consumption and urinary habits although these signs may not be noticed by some owners, particularly if cats spend
significant time outside. Subtle weight loss is often one of the first physical findings in CPRD. Other physical findings
might include reduced renal size, changes in renal consistency, renal irregularity or disparity in renal sizes, halitosis,
stomatitis, and constipation. Retinal examination may reveal hemorrhages or retinal detachment secondary to renal-associated
We encourage "senior cat" profiling after the age of 8 years. However, the decision to perform laboratory testing should not
be based on age alone. Our minimum baseline laboratory evaluation includes a complete blood count, serum biochemistry profile
and electrolytes, total T4, and urinalysis (by cysto). Beware of over- or under-interpretation of marginal elevations of BUN
and creatinine levels and remember that these measures of renal function must always be assessed with respect to patient hydration
status and urine specific gravity. Cats do not follow the 66% (isosthenuria) - 75% (azotemia) rule of dogs. That is, cats
do not become isosthenuric when they lose 2/3 of their renal mass and they can be in overt renal failure without isosthenuria.
Because cats are descended from desert animals, they have much better normal renal concentration abilities than do dogs. A
normally hydrated cat can produce urine with a specific gravity of 1.095 or greater. Therefore, in order to be considered
to have adequate urine concentration abilities, a cat should have a USG of > 1.035.
If abnormalities are recognized that indicate the presence of CPRD, additional studies are performed including abdominal radiography
and ultrasonography, and blood pressure measurement (Doppler). The earliest change seen on US examination is lack of corticomedullary
differentiation. Because cats with CPRD do not concentrate urine well, they are more prone to developing true urinary tract
infection. For whatever reason, inflammatory sediment is often not seen in the urine sediment on UA in these patients. We
submit a urine culture in all cats with CPRD to detect those with occult infection. Cats with protein-losing nephropathy have
a poor prognosis and additional interventional steps may be important in their management. Dipstick assessment of urine protein
is often misleading and the ERD® test is not sufficiently quantitative to critically assess the true severity of protein loss.
We perform a urine protein/creatinine ratio in all cats with CPRD. Kidney biopsy is rarely performed if CPRD is suspected
because there is no specific therapy other than to address the changes associated with the disease that are identical regardless
of the underlying etiology of the renal damage.
Increase water consumption/Maintain hydration
Older cats have a decreased thirst drive and a decreased thirst response to dehydration compared to younger cats. This will
contribute to and aggravate the impact of CPRD-associated azotemia. In addition, these cats will be doubly prone to developing
significant azotemia if water intake is restricted for any reason. Efforts to increase voluntary water consumption include
providing clean, fresh water at all times, feeding a canned food diet (with added water if possible), offering beef or chicken
broth (low sodium), bottled clam juice, or "tuna juice". Many cats enjoy drinking the water squeezed from cans of tuna. I
have owners use a blender to mix a can of tuna with water, pour the mixture into ice cube trays and freeze, then pop cubes
out into a plastic bag for freezer storage. These tuna juice cubes can be thawed out one at a time for the cat to enjoy. Cats
that like to drink from running water sources (faucets, etc) may drink more enthusiastically from a recirculating water fountain
than a water bowl. These drinking fountains are available at many pet stores.