Eosinophilic granuloma complex is a dermatologic condition most commonly seen in cats. Allergies such as food allergy, atopy
and insect hypersensitivities have been associated with this syndrome. If the allergic cause for this dermatitis is not found
than the EGC is described as being idiopathic. No age or breed predilection exists. However, reports exist that suggest
that female cats may be predisposed to developing EGC. Several clinical syndromes have been described for cats with EGC.
These syndromes are: indolent ulcer (eosinophilic ulcer or rodent ulcer), eosinophilic plaque, eosinophilic granuloma. Each
of these syndromes varies and they will be discussed separately.
Indolent ulcer lesions have a distinctive appearance to them. Indolent ulcers are ulcerative lesions with a raised border.
The most common location for rodent ulcers is the upper lip. Other areas where these skin lesions can be present are: oral
cavity and other areas of the skin (possible but not as common). Pruritus and pain are rarely noted.
Differential diagnoses for indolent ulcers are infection (bacterial and/or fungal), trauma, neoplasia (ie SCC, cutaneous lymphosarcoma,
mast cell tumor), and virally induce lesions (ie FeLV and/or FIV).
Eosinophilic plaque is single or multiple plaques which are most commonly ulcerated. These types of EGC lesions are most
commonly seen on the abdomen, medial thighs and other body locations (i.e. conjunctiva, cornea). Severe pruritus and peripheral
lymphadenopathy are other clinical signs that can be seen with eosinophilic plaques.
The differential diagnoses for eosinophilic plaque are infection, trauma, neoplasia and virally induced lesions.
This syndrome appears as raised plaque lesions in a linear configuration. Erosion and ulcerations are possible. Eosinophilic
granulomas are caudal thighs, face, and oral cavity. A peripheral lymphadenopathy is possible.
Differential diagnoses for EGC
Differential diagnoses for EGC are: infection (bacterial and/or fungal), trauma with or without a secondary infection, neoplasia
(i.e. squamous cell carcinoma, cutaneous lymphoma, mast cell tumor), and virally induced lesions (i.e. FeLV and/or FIV) which
may or may not be secondarily infected.