Infectious causes of feline diarrhea (Proceedings) - Veterinary Healthcare
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Infectious causes of feline diarrhea (Proceedings)


CVC IN BALTIMORE PROCEEDINGS


Histoplasmosis: Epidemiology

      • Histoplasma capsulatum
      o Worldwide distribution
      o Most prevalent: Missouri, Ohio, Mississippi River Valleys
      o Most commonly diagnosed human systemic mycosis
      o Sporulation enhanced in presence of bird and bat guano
      o Very environmentally resistant
      o Contaminated soil present >15 years after removal
      • Infection
      o Inhalational
      o Ingestion
      o (Disrupted skin)
      • Pathophysiology
     o Phagocytosis: RE system
     o Dissemination or pulmonary disease?
      o Lymphatics/hematogenously
      • Clinical presentation
      o Dogs
      <4 years of age
      Gender variable
      Pointers? Brittany spaniels?
      o Cats
      2nd most commonly diagnosed
      Gender variable
      Persians
      • Clinical presentation
      • Pulmonary
      • Acute: uncommon (contrast to human)
      • Chronic: canine
      • Disseminated
      o Chronic Pulmonary
      Mild cough
      Weight loss/inappetance
      Hilar lymphadenopathy

      o Disseminated : feline
      GI NOT common
      Bony lesions (lysis)
      Weight loss
      Fever
      Lymphadenopathy
      Pulmonary: miliary interstitial, not lymphadenopathy
      Chorioretinitis
      Hepatic/icterus
      • Diagnosis
      o Travel history (not necc recent)
      o Demonstration of organism
      o 2-4 um
      o Shrinkage of capsule
      o Intracellular (or free)
      o Lymph node aspirate CBC Bone marrow Rectal scraping (dogs)
      o Diagnosis
      Serology (CF): false negatives and positives
      9 of 11 negative in dogs


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Source: CVC IN BALTIMORE PROCEEDINGS,
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