• Primary injury
o Direct parenchymal and vascular damage
o Occurs immediately as a result of traumatic event
• Secondary injury
o Result of biochemical cascades initiated by primary injury
o Includes ATP depletion, increases in intracellular Na+ and Ca2+ as well as extracellular excitatory neurotransmitters,
production of oxygen free radicals, increased cytokine production, accumulation of nitric oxide, lactic acidosis and activation
of arachidonic acid, kinin, complement, coagulation and fibrinolytic cascades
o Results in further damage to nervous tissue
o Therapy directed at minimizing secondary injury
• Initial neurologic evaluation
o Important components of neurologic exam
▪ Motor/Posture – ambulatory vs. recumbent, muscle tone and voluntary movements, Schiff-Sherrington posture
▪ Segmental reflexes – tendon, withdrawal, panniculus and perineal reflexes
▪ Pain perception – assessed via behavioral response to a noxious stimulus
»
Superficial – elicited from pinch of the skin/SQ tissues
»
Deep – elicited from pinch of bone/digit
▪ Mentation and cranial nerve evaluation can generally be performed without significant patient manipulation
o Scoring system has been described for acute spinal cord injury in dogs
o Initial neurologic status may improve following immediate stabilization
• Management of TSCI
o Immobilization
o Hemodynamic stabilization
▪ Resuscitation for maintenance of normotension, adequate oxygen levels
»
Often concurrent injuries involving other areas – cardiovascular, respiratory, abdominal, brain trauma
▪ CBC, chemistry panel, electrolytes, UA and thoracic radiographs can help define extent of injuries
o Analgesia
o Imaging
▪ Radiographs – screening lateral views safe; VD views only with a horizontal beam technique if potential for
instability exists
▪ CT – excellent bone detail, evidence of hemorrhage may be seen
▪ Myelography – used to evaluate potential spinal cord compression
▪ MRI – for evaluation of extrinsic and intrinsic spinal cord lesions
o Medical management to reduce secondary injury
▪ Corticosteroids
»
Use controversial in human and veterinary medicine
» Methylprednisolone has been extensively evaluated; evidence suggests benefit related more to free radical
scavenging than anti-inflammatory properties; other commonly used steroids (e.g. prednisone, dexamethasone) do not have free
radical scavenging capabilities
» National Acute Spinal Cord Injury Study trials in humans
o Small improvements (in motor scores at 6 weeks and pinprick and touch sensation at 6 months post
injury) noted in TSCI patients administered methylprednisolone within 8 hours of injury; detrimental >8h; no difference
in outcome vs. control groups at 1 year; increased risk of pneumonia and trend towards sepsis with methylprednisolone therapy
»
A study in dogs showed timely surgical decompression of acute compressive spinal cord injury was more effective for improving
neurologic recovery than methylprednisolone without surgery
» A study of dachshunds administered methylprednisolone and having surgical decompression following IVD
herniation showed increased post-operative complications (melena, diarrhea, emesis, hematemesis and anorexia) and higher medical
bills vs. dogs not receiving methylprednisolone Polyethylene glycol (PEG)
»
Use shown to be safe in dogs
»
Ongoing studies for evaluation of efficacy in spinal cord injury
▪ N-acetylcysteine has been investigated to prevent oxidative secondary injury in dogs, but did not prove to
have clinical benefit in a randomized blinded placebo-controlled clinical trial
