Plasma Cell Pododermatitis
The etiology of this unusual condition in cats is not known. It probably falls into the category of other lymphoproliferative
disorders of cats.
Clinical signs include soft, puffy swelling of one or more of the footpads. The metacarpal and metatarsal pads are most frequently
affected. The condition usually affects more than one foot but occasionally unipedal involvement is observed. Surprisingly,
affected feet do not seem to be painful unless ulceration of the pads occurs. Secondary infection may occur in ulcerated
The clinical appearance is fairly classical if several feet are involved. Confirmation can be made by fine needle aspiration
(FNA) or biopsy. The aspirate will usually include numerous RBCs mixed with plasma cells and some neutrophils. Neutrophils
may be more numerous if there is secondary infection in an ulcerated pad.
Occasionally this condition will regress spontaneously, however, treatment is recommended. Doxycycline (10 mg/kg PO q24h)
may be effective, most likely because of its anti-TNFα effects. Glucocorticoids (oral or repositol) will usually produce
regression. Other immunosuppressive drugs such as cyclosporine may be helpful but have not been used as often. The prognosis
for recovery from this condition is good.
Cutaneous horns are composed of keratin overgrowth. They may affect one or multiple footpads. Often thin and horn-like (hence
the name), they may appear like second "nails" close to the nails on the digital pads. If not on a weight bearing surface,
these lesions usually do not cause lameness. If on the plantar surfaces of the pads, they may cause discomfort in walking.
Cutaneous horns may be spontaneous, and this is often the case on the footpads. Horns are also associated with papillomavirus
infection, FeLV, and squamous cell carcinoma. Diagnosis of the condition is usually based on the appearance of the lesions.
Affected cats should be tested for FeLV because this is an easy rule-out diagnosis. Single horns associated with scaly skin
lesions should be biopsied to rule out SCC.
If the horns are not causing lameness the lesions are often ignored. The horny growth can removed by trimming, however, the
horns will often recur. Horns causing discomfort should be removed and, if it is possible to do so without causing a large
pad defect, the base of the lesion should be excised to prevent re-growth.