Agents for HCM therapy in cats (Proceedings)
Feline hypertrophic cardiomyopathy is a challenging disease for veterinarians given its heterogeneous nature and the large segment of HCM cats that are asymptomatic. A genetic basis has been suspected for a long time and recently disease-associated mutations in myosin-binding protein C have been documented in Maine coons and ragdolls1,2. However, phenotypic differences in the disease across the wider spectrum of cats are remarkable. Treatment of asymptomatic cats is still largely empirical and controversial. Treatment of symptomatic cats has evolved over the last few years as data from multicenter clinical trials has become available. Understanding the relation between the disease pathophysiology and the clinical pharmacodynamics of drugs used in the management of this disease is crucial to make appropriate therapeutic decisions.
Objectives Of The Presentation
1. To briefly discuss the pathophysiology of this disease.
Key Pathophysiologic Points
1. Distinguishing the different forms of feline myocardial disease is not straightforward, which complicates its management.
Relevant Therapeutic Points
1. Evidence for drug effect on the progression of HCM in asymptomatic cats is lacking11. Beta-adrenergic blockers, angiotensin converting enzyme inhibitors (ACEI), calcium channel blockers, and spironolactone
are often administered to cats with HCM that are not in heart failure. The rationale can be found in the well established
thought that treatment before CHF symptoms may slow the progression of the disease. A recent study has shown that treatment
of asymptomatic cats with ACEI may not be warranted12.
Drugs, Dosages and Indications
2. Placebo-controlled studies with spironolactone alone (4 months) failed to show beneficial effects in cats with HCM that were not in heart failure13.
3. Treatment of acute heart failure is more dependent on the stage of presentation than on the type of disease3.
4. Therapy of acute heart failure may include oxygen, diuretics, and venodilators.
a) Furosemide is the most common diuretic used in cats with acute pulmonary edema. Dose up to 2-4 mg/kg IV, IM every 1-2 hours initially, monitoring renal function, blood pressure and electrolytes. Dose should be decrease considerably when acute signs are under control.
b) 2% nitroglycerin cream (1/8" – 1/4" q4-6h for the first 24 hr) is a common venodilator for acute onset of CHF. However, nitroglycerin tolerance develops quickly in humans and likely in cats as well.
c) Cat should rest in an oxygen enriched environment and might need to be sedated.
d) Severely dyspneic cats may need to be sedated and pleural effusion might be needed.
5. Maintenance therapy of moderate CHF in HCM cats typically involves furosemide and ACEIs. Adjuvant therapy may include calcium-channel blockers or beta-blockers, after the CHF symptoms are controlled.
a) Furosemide is typically given at 1.5-3 mg/kg (6.25-12.5 mg/cat) q8-24h PO to address pulmonary edema. After cessation of heart failure symptoms, furosemide dose should be titrated to the lowest effective dose. High-dose therapy results in moderate pre-renal azotemia, which often can be tolerated.
b) Enalapril, benazepril or ramipril can be used as ACEI. Although there are pharmacokinetic differences among them, there is evidence that they can be used indistinctly. Interindividual PK variability of ACEI is important, so doses should be titrated to individual patients. In a study, benazepril did not worsen the severity of outflow obstruction in cats with hypertrophic obstructive cardiomiopathy14. However, recent studies suggest that ACEI therapy may add little benefit to cats already treated with furosemide15. However, this was small and presented only in abstract form.
• Enalapril is started at 0.25-2.5 mg/kg q24h PO.
• Benazepril is started at 0.25-0.5 mg/kg q24h PO.
• Ramipril is started at 0.5 mg/kg q24h PO.
c) Antiarrhythmic drugs like atenolol or diltiazem are commonly used as adjunctive agents, although there is evidence to suggest that diltiazem in not helpful in prolonging survival and that atenolol could be detrimental. Their utility in cats with HCM is therefore controversial, none of them produce remarkable benefits and many cardiologists have abandoned their use.
• Atenolol can be started at 6.25-12.5 mg/cat q12h PO. (Roughly 3 mg/kg).
• Diltiazem can be started at 1.75-2.4 mg/kg q8h PO. Tablets may be difficult to break for cats.
d) Spironolactone might be beneficial but recent studies have failed to demonstrate any benefit13.
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