Basic approach to evaluating solid tissue tumor cytology (Proceedings)

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Basic approach to evaluating solid tissue tumor cytology (Proceedings)

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Aug 01, 2011

Lump or bump

An epidermal, dermal, or subcutaneous mass lesion that is easily accessible to aspiration cytology

Goal of aspiration cytology

• To direct next step of therapy or diagnostics (at the minimum)
• To definitively diagnose the cause of the lesion
• To advise owners of most probable process

What makes it a lump?

• Expansion of tissue
• Tissue fluid
• Infiltration cells
• Overgrowth of resident cells

Overall question

• What is the process that is causing this expansion?
• Subquestions:
     o What is the treatment?
     o What is the prognosis?

Obtaining the sample

• Fine needle biopsy (aspirates)
     o Preferred method for masses
• Impression smear
• Scraping
• Swab

Staining

• Romanowsky stains
     o Metachromatic reaction
• Romanowsky-like stains (Diff-Quik)
     o Mast cells may not stain