Canine clinical cases (Proceedings)


Canine clinical cases (Proceedings)

Nov 01, 2009

Case #1


  • 18 month old female intact Plott hound, "Donna"
  • Bloody discharge that started approximately 4 1/2 weeks ago
  • Discharge has increased and decreased during this time
  • This is the first heat, and the owner would like to breed her

Clinical findings

  • HR, RR, temperature normal
  • Weight: 57 pounds
  • Bloody vulvar discharge

  • Proestrus
  • Estrus
  • Endocrine Producing Ovarian Tumor
  • Cystic Ovaries.
  • Exogenous Estrogens

Possible diagnostics

  • Vaginal Cytology

     o Is the reproductive tract normal?
  • Progesterone Assay

     o Has progesterone started to elevate?
  • LH concentration: No Value!
  • Estradiol

     o No more value than a cytology!
  • Ultrasound of the reproductive tract

     o Rarely of value, except to locate follicular like structures or tumors on the ovaries
  • Karyotyping: Not indicated
  • CBC, profile, urinalysis

     o May be performed if indicated
  • Thyroid panel
  • Radiographs

     o Unnecessary
  • Laparoscopic examination or exploratory laparotomy may be considered

     o Rarely of value in a bitch with these signs!

Diagnostic test findings

  • Vaginal Cytology

     o Normal proestrous/estrous cytology

Differential diagnoses

  • Proestrus - Too long for normal proestrus
  • Estrus - Not typical of normal estrus
  • Endocrine Producing Ovarian Tumor - Rare
  • Exogenous Estrogens - Watch the clover and birth control pills!


  • Cystic Ovaries

     o Diagnosis based on history (proestrus should not last over 18 days), and vaginal cytology
     o History must rule out exogenous estrogens!


  • Miberolone

     o 18 mcg/lb for 5 to 10 days
  • Testosterone

     o 2 mg/kg up to 30 mg?
  • Ovaban - Megestrol acetate
  • hCG - 500 to 1000 units/animal

  • GnRH

Expected results

  • Our treatment with hCG is 95% successful
  • Signs decrease within 5 days and should be gone by 14 days
  • Two treatments are 100% successful