Infectious causes of feline diarrhea (Proceedings)

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Infectious causes of feline diarrhea (Proceedings)

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Apr 01, 2010
1234Next Histoplasmosis: Epidemiology       • Histoplasma capsulatum       o Worldwide distribution       o Most prevalent: Missouri, Ohio, Mississippi River Valleys       o Most commonly diagnosed human systemic mycosis       o Sporulation enhanced in presence of bird and bat guano       o Very environmentally resistant       o Contaminated soil present >15 years after removal       • Infection       o Inhalational       o Ingestion       o (Disrupted skin)       • Pathophysiology      o Phagocytosis: RE system      o Dissemination or pulmonary disease?       o Lymphatics/hematogenously       • Clinical presentation       o Dogs       ¢ <4 years of age       ¢ Gender variable       ¢ Pointers? Brittany spaniels?       o Cats       ¢ 2nd most commonly diagnosed       ¢ Gender variable       ¢ Persians       • Clinical presentation       • Pulmonary       • Acute: uncommon (contrast to human)       • Chronic: canine       • Disseminated       o Chronic Pulmonary       ¢ Mild cough       ¢ Weight loss/inappetance       ¢ Hilar lymphadenopathy       o Disseminated : feline       ¢ GI NOT common       ¢ Bony lesions (lysis)       ¢ Weight loss       ¢ Fever       ¢ Lymphadenopathy       ¢ Pulmonary: miliary interstitial, not lymphadenopathy       ¢ Chorioretinitis       ¢ Hepatic/icterus       • Diagnosis       o Travel history (not necc recent)       o Demonstration of organism       o 2-4 um       o Shrinkage of capsule       o Intracellular (or free)       o Lymph node aspirate CBC Bone marrow Rectal scraping (dogs)       o Diagnosis       ¢ Serology (CF): false negatives and positives       ¢ 9 of 11 negative in dogs 1234Next