- Hepatic lipidosis accounts for approximately 50% of feline liver disease
- Excessive accumulation of fat in the liver
- Can be primary or secondary
- Early diagnosis makes for the best prognosis!!
- Majority of cats have history of obesity, may still be obese at time of detection
- Any age, no breed or sex predilection
- Typically a history of some sort of stress to the cat
o Food change
o Housing change
o Infection/other disease
o Inappetance for days to weeks
Physical exam findings
- Weight loss
- Muscle wasting
- +/- history of vomiting
- Icterus occurs gradually
- Mild hepatomegaly
- With severe liver failure, signs of hepatic encephalopathy may be present, clotting disorders may be present
- Elevated AlkPhos, NORMAL GGT
- Alt and Ast typically not as significantly elevated
- CBC – boring, possible stress leukogram
- If lipidosis is secondary to other disease process, there may be evidence of primary disease on bloodwork results
- Rads – mild hepatomegaly
- Ultrasound – hyperechoic liver
- Definitive diagnosis is made with biopsy
- Hemolytic disease?
- Any cholestatic disease process
- Aggressive nutritional support
- Manage concurrent disease if present
- Greater success rate with earlier detection, can be over 80% if caught early and treated aggressively
- If signs of more significant liver failure are present (hepatic encephalopathy, clotting disorders) prognosis for survival is <40%
- Once recovered, there is no increased risk of further liver disease or recurrence of lipidosis
- Hospitalize the cat – manage fluid and electrolyte imbalances
- Place a feeding tube – whichever kind you are comfortable with
- Control vomiting
- Feed the cat!
o 50% of nutritional needs (based on a healthy weight) divided among several feedings for the first 1-2 days
o If tolerating feedings well, increase to 100% of nutritional needs by day 4-5.
o Do not offer any food until after day 5-7. Ok to leave water available.
o Make sure hydration needs are being met as well.
- Weigh the cat weekly
- Change bandage weekly or as needed
- Support the client!!
- Manage concurrent diseases or issues