Understanding pain pathways and pharmacologic targets (Proceedings)
The COX Pathway
• Most commonly used veterinary pain drug
Acetaminophen• Belongs in a class of its own
• There have been many attempts to classify it. It probably works by binding to cannabinoid receptors but other possible pathways include COX, seratonin, opioid, norepinephrine and nitric oxide
• It only seems to work in some dogs, never use in cats. It is a good adjunct medicine to try out, but I would never use it by itself...not dependable enough.
• Dog Dose is 10 mg/kg q8-12h
• Good analgesic effect for patients with osteosaroma, especially those with metastatic diesease. Biphosphonates inhibit osteoclastic activitiy, thereby reducing bone resorption and they promote repair through stimulation of osteoblast differentiation and bone formation. They have poor oral absorption so are given by the IV route.